SCG3

Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.^[5][6]

SCG3
Identifiers
Aliases	SCG3, SGIII, secretogranin III
External IDs	OMIM: 611796; MGI: 103032; HomoloGene: 7526; GeneCards: SCG3; OMA:SCG3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.2 Start 51,681,492 bp[1] End 51,721,026 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 D|9 42.32 cM Start 75,550,471 bp[2] End 75,591,338 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans beta cell dorsolateral prefrontal cortex right frontal lobe Brodmann area 9 anterior cingulate cortex prefrontal cortex ganglionic eminence Amygdala caudate nucleus Top expressed in deep cerebellar nuclei islet of Langerhans pontine nuclei medial vestibular nucleus dorsal tegmental nucleus cerebellar vermis arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding Cellular component extracellular region secretory granule lumen transport vesicle membrane membrane cytoplasmic vesicle endoplasmic reticulum lumen secretory granule membrane transport vesicle Biological process platelet degranulation post-translational protein modification protein localization to secretory granule Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29106 20255 Ensembl ENSG00000104112 ENSMUSG00000032181 UniProt Q8WXD2 P47867 RefSeq (mRNA) NM_013243 NM_001165257 NM_001164790 NM_009130 RefSeq (protein) NP_001158729 NP_037375 NP_001158262 NP_033156 Location (UCSC) Chr 15: 51.68 – 51.72 Mb Chr 9: 75.55 – 75.59 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.^[6]