SCGB1D2

Secretoglobin family 1D member 2 is a protein that in humans is encoded by the SCGB1D2 gene.^[3][4][5]

SCGB1D2
Identifiers
Aliases	SCGB1D2, LIPB, LPHB, LPNB, secretoglobin, family 1D member 2, secretoglobin family 1D member 2
External IDs	OMIM: 615061; HomoloGene: 88740; GeneCards: SCGB1D2; OMA:SCGB1D2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,242,239 bp[1] End 62,244,812 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube skin of thigh epithelium of lactiferous gland corpus epididymis skin of arm lactiferous duct skin of hip skin of abdomen endometrium olfactory zone of nasal mucosa n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10647 n/a Ensembl ENSG00000124935 n/a UniProt O95969 n/a RefSeq (mRNA) NM_006551 n/a RefSeq (protein) NP_006542 n/a Location (UCSC) Chr 11: 62.24 – 62.24 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.^[5]

SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cells.^[6]