SCUBE1

Signal peptide, CUB domain and EGF like domain containing 1 is a protein that in humans is encoded by the SCUBE1 gene. ^[5]

SCUBE1
Identifiers
Aliases	SCUBE1, signal peptide, CUB domain and EGF like domain containing 1
External IDs	OMIM: 611746; MGI: 1890616; HomoloGene: 11224; GeneCards: SCUBE1; OMA:SCUBE1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 43,197,280 bp[1] End 43,343,372 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,489,200 bp[2] End 83,609,222 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa tibia tibial nerve left ovary sural nerve ganglionic eminence right ovary ventricular zone gonad Skeletal muscle tissue of rectus abdominis Top expressed in genital tubercle habenula visual cortex superior frontal gyrus primary visual cortex third ventricle urethra female urethra male urethra infundibular recess More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding identical protein binding protein heterodimerization activity Cellular component extracellular region cell surface extrinsic component of plasma membrane membrane external side of plasma membrane extracellular space plasma membrane Biological process endothelial cell differentiation blood coagulation inflammatory response protein homooligomerization post-embryonic development adult heart development signal transduction cell differentiation positive regulation of smoothened signaling pathway extracellular matrix disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80274 64706 Ensembl ENSG00000159307 ENSMUSG00000016763 UniProt Q8IWY4 Q6NZL8 RefSeq (mRNA) NM_173050 NM_001271472 NM_001271473 NM_022723 RefSeq (protein) NP_766638 NP_766638.2 NP_001258401 NP_001258402 NP_073560 Location (UCSC) Chr 22: 43.2 – 43.34 Mb Chr 15: 83.49 – 83.61 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology.