Syntenin-1

Syntenin-1 is a protein that in humans is encoded by the SDCBP gene.^[5]

SDCBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N99, 1NTE, 1OBX, 1OBY, 1OBZ, 1R6J, 1V1T, 1W9E, 1W9O, 1W9Q, 1YBO, 4Z33
Identifiers
Aliases	SDCBP, MDA-9, ST1, SYCL, TACIP18, MDA9, syndecan binding protein
External IDs	OMIM: 602217; MGI: 1337026; HomoloGene: 4110; GeneCards: SDCBP; OMA:SDCBP - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q12.1 Start 58,552,924 bp[1] End 58,582,859 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 6,365,650 bp[2] End 6,408,423 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium visceral pleura amniotic fluid palpebral conjunctiva parietal pleura germinal epithelium blood skin of hip ganglionic eminence monocyte Top expressed in stroma of bone marrow gastrula fetal liver hematopoietic progenitor cell pyloric antrum calvaria tibiofemoral joint atrioventricular valve right lung mucous cell of stomach submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding frizzled binding protein binding identical protein binding cytoskeletal anchor activity interleukin-5 receptor binding phosphatidylinositol-4,5-bisphosphate binding lipid binding cadherin binding syndecan binding protein heterodimerization activity Cellular component cytoplasm extracellular vesicle blood microparticle endoplasmic reticulum membrane membrane focal adhesion melanosome adherens junction plasma membrane cell junction endoplasmic reticulum membrane raft extracellular exosome cytoskeleton nucleus extracellular region extracellular space nucleoplasm cytosol interleukin-5 receptor nuclear membrane azurophil granule lumen intracellular membrane-bounded organelle Biological process positive regulation of transforming growth factor beta receptor signaling pathway intracellular signal transduction positive regulation of extracellular exosome assembly negative regulation of receptor internalization protein targeting to membrane ephrin receptor signaling pathway substrate-dependent cell migration, cell extension positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of JNK cascade positive regulation of epithelial to mesenchymal transition regulation of mitotic cell cycle negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of exosomal secretion positive regulation of phosphorylation actin cytoskeleton organization chemical synaptic transmission positive regulation of cell population proliferation positive regulation of cell growth positive regulation of cell migration neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6386 53378 Ensembl ENSG00000137575 ENSMUSG00000028249 UniProt O00560 O08992 RefSeq (mRNA) NM_001007067 NM_001007068 NM_001007069 NM_001007070 NM_005625 NM_001330537 NM_001348339 NM_001348340 NM_001348341 NM_001098227 NM_016807 RefSeq (protein) NP_001007068 NP_001007069 NP_001007070 NP_001007071 NP_001317466 NP_005616 NP_001335268 NP_001335269 NP_001335270 NP_001091697 NP_058087 Location (UCSC) Chr 8: 58.55 – 58.58 Mb Chr 4: 6.37 – 6.41 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

Interactions

SDCBP has been shown to interact with:

• EFNB1,^[7]
• GRIK1,^[8]
• GRIK2,^[8][9]
• Interleukin 5 receptor alpha subunit,^[10]
• Merlin,^[11]
• RAB5A,^[12]
• SOX4,^[10]
• TRAF6,^[13]
• ULK1.^[12] and
• ERICH2^[14]