RAB5A

Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene.^[5][6]

RAB5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N6H, 1N6I, 1N6K, 1N6L, 1N6N, 1N6O, 1N6P, 1N6R, 1R2Q, 1TU3, 1TU4, 3MJH, 4Q9U
Identifiers
Aliases	RAB5A, RAB5, member RAS oncogene family
External IDs	OMIM: 179512; MGI: 105926; HomoloGene: 68142; GeneCards: RAB5A; OMA:RAB5A - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.3 Start 19,947,097 bp[1] End 19,985,175 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 C|17 27.82 cM Start 53,786,262 bp[2] End 53,814,708 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium endothelial cell lower lobe of lung skin of thigh corpus epididymis Pons pars compacta human penis pars reticulata Medulla Oblongata Top expressed in esophagus ganglionic eminence hippocampus proper lens primary visual cortex cerebellar cortex right kidney zone of skin superior frontal gyrus neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding GTP binding protein binding GTPase activity guanyl nucleotide binding Cellular component cytoplasm axon terminus endosome cell projection membrane synaptic vesicle melanosome ruffle plasma membrane endocytic vesicle axon soma terminal bouton dendrite somatodendritic compartment early endosome phagocytic vesicle actin cytoskeleton membrane raft cytoplasmic side of early endosome membrane extracellular exosome cytoplasmic vesicle phagocytic vesicle membrane cytosol endosome membrane clathrin-coated vesicle membrane early endosome membrane early phagosome postsynaptic early endosome anchored component of synaptic vesicle membrane Biological process regulation of endocytosis regulation of filopodium assembly endocytosis blood coagulation receptor internalization involved in canonical Wnt signaling pathway regulation of autophagosome assembly synaptic vesicle recycling early endosome to late endosome transport transport protein transport positive regulation of exocytosis regulation of synaptic vesicle exocytosis regulation of endosome size viral RNA genome replication phagocytosis phosphatidylinositol biosynthetic process membrane organization post-translational protein modification intracellular protein transport Rab protein signal transduction regulation of long-term neuronal synaptic plasticity amyloid-beta clearance by transcytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5868 271457 Ensembl ENSG00000144566 ENSMUSG00000017831 UniProt P20339 Q9CQD1 RefSeq (mRNA) NM_004162 NM_001292048 NM_025887 RefSeq (protein) NP_001278977 NP_004153 NP_080163 Location (UCSC) Chr 3: 19.95 – 19.99 Mb Chr 17: 53.79 – 53.81 Mb PubMed search [3] [4]
Wikidata
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Function

RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to early endosomes.^[7] It drives the maturation of endosomes by transporting vacuolar (H+)-ATPases (V-ATPases) from trans-Golgi network to endocytic vesicles.^[8]

Interactions

RAB5A has been shown to interact with:

• CHML,^[9][10]
• RABEP1,^{[11][12][13][14]}
• SDCBP,^[15] and
• ZFYVE20^[16]