SDK1

Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. ^{[5] [6]}

SDK1
Identifiers
Aliases	SDK1, sidekick cell adhesion molecule 1
External IDs	OMIM: 607216; MGI: 2444413; HomoloGene: 27395; GeneCards: SDK1; OMA:SDK1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.2 Start 3,301,252 bp[1] End 4,269,000 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 141,227,245 bp[2] End 142,201,341 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery decidua tibial arteries body of pancreas sural nerve islet of Langerhans olfactory zone of nasal mucosa gonad Descending thoracic aorta ascending aorta Top expressed in otolith organ utricle Jacobson's organ gastrula internal carotid artery genital tubercle lens external carotid artery zygote sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function identical protein binding Cellular component integral component of membrane cell junction synapse membrane plasma membrane Biological process synapse assembly cell adhesion retina layer formation regulation of dendritic spine development behavioral response to cocaine homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221935 330222 Ensembl ENSG00000146555 ENSMUSG00000039683 UniProt Q7Z5N4 Q3UH53 RefSeq (mRNA) NM_001079653 NM_152744 NM_177879 RefSeq (protein) NP_001073121 NP_689957 NP_808547 Location (UCSC) Chr 7: 3.3 – 4.27 Mb Chr 5: 141.23 – 142.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily.^[7] The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].