SDPR

Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene.^[5][6][7] Cavin-2 is highly expressed in a variety of human endothelial cells.^[8]

CAVIN2
Identifiers
Aliases	CAVIN2, PS-p68, SDR, cavin-2, SDPR, serum deprivation response, caveolae associated protein 2
External IDs	OMIM: 606728; MGI: 99513; HomoloGene: 3422; GeneCards: CAVIN2; OMA:CAVIN2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q32.3 Start 191,834,310 bp[1] End 191,847,088 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C1.1 Start 51,328,285 bp[2] End 51,342,119 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte lower lobe of lung right lung upper lobe of lung superficial temporal artery upper lobe of left lung parietal pleura abdominal fat gallbladder pericardium Top expressed in right lung right lung lobe left lung left lung lobe vestibular membrane of cochlear duct atrioventricular valve atrium white adipose tissue tunica adventitia of aorta carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylserine binding protein binding phospholipid binding protein kinase C binding lipid binding Cellular component cytoplasm membrane raft cytosol membrane caveola nucleoplasm plasma membrane actin cytoskeleton Biological process plasma membrane tubulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8436 20324 Ensembl ENSG00000168497 ENSMUSG00000045954 UniProt O95810 Q63918 RefSeq (mRNA) NM_004657 NM_138741 RefSeq (protein) NP_004648 NP_620080 Location (UCSC) Chr 2: 191.83 – 191.85 Mb Chr 1: 51.33 – 51.34 Mb PubMed search [3] [4]
Wikidata
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This gene has a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.^[7]

Function

Cavin-2 is required for blood vessel formation (angiogenesis) in humans and zebrafish and required also for the endothelial cell proliferation, migration and invasion in humans.^[8] Cavin-2 plays an important role in endothelial cell maintenance by regulating eNOS activity.^[8] Cavin-2 controls the generation of nitric oxide (NO) in human endothelial cells by controlling the activity and stability of the protein endothelial nitric-oxide synthase (eNOS).^[8]

Secretion

Cavin-2 is highly secreted from human endothelial cells (HUVEC), they are secreted through endothelial microparticles (EMPs) but not exosomes and is required for EMP biogenesis.^[8]

Clinical significance

SDPR is shown to act as a metastasis suppressor by xenograft studies utilizing breast cancer cell lines.^[9] SDPR may elicit its metastasis suppressor function by directly interacting with ERK and limiting its pro-survival role.^[9] Moreover, it is suggested that SDPR is silenced during breast cancer progression by promoter DNA methylation.^[9] Metastasis suppressor role of SDPR may go beyond breast cancer since tumor samples from bladder, colorectal, lung, pancreatic, and ovarian cancers as well as sarcomas also exhibited loss of SDPR expression.^[9]