SEC14L2

SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2.^[5][6]

SEC14L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O6U, 1OLM, 4OMJ, 4OMK,%%s1O6U, 1OLM
Identifiers
Aliases	SEC14L2, C22orf6, SPF, TAP, TAP1, SEC14 like lipid binding 2
External IDs	OMIM: 607558; MGI: 1915065; HomoloGene: 8245; GeneCards: SEC14L2; OMA:SEC14L2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,396,941 bp[1] End 30,425,303 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 4,047,039 bp[2] End 4,073,415 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right frontal lobe prefrontal cortex nucleus accumbens Amygdala C1 segment cingulate gyrus caudate nucleus putamen anterior cingulate cortex Top expressed in superior surface of tongue left lobe of liver gallbladder olfactory epithelium yolk sac neural layer of retina dentate gyrus of hippocampal formation granule cell jejunum retinal pigment epithelium cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vitamin E binding phospholipid binding lipid binding transporter activity Cellular component cytoplasm integral component of membrane extracellular exosome intracellular anatomical structure nucleus cytosol Biological process regulation of cholesterol biosynthetic process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23541 67815 Ensembl ENSG00000100003 ENSMUSG00000003585 UniProt O76054 Q99J08 RefSeq (mRNA) NM_033382 NM_001204204 NM_001291932 NM_012429 NM_144520 RefSeq (protein) NP_001191133 NP_001278861 NP_036561 NP_203740 NP_036561.1 NP_653103 Location (UCSC) Chr 22: 30.4 – 30.43 Mb Chr 11: 4.05 – 4.07 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in metabolism of cholesterol.^[6]