SEC24C

Protein transport protein Sec24C is a protein that in humans is encoded by the SEC24C gene.^[5][6][7]

SEC24C
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EH2
Identifiers
Aliases	SEC24C, SEC24 homolog C, COPII coat complex component
External IDs	OMIM: 607185; MGI: 1919746; HomoloGene: 3615; GeneCards: SEC24C; OMA:SEC24C - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.2 Start 73,744,372 bp[1] End 73,772,161 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 20,724,376 bp[2] End 20,744,920 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx islet of Langerhans granulocyte stromal cell of endometrium anterior pituitary right adrenal gland left adrenal gland right adrenal cortex left adrenal cortex smooth muscle tissue Top expressed in tail of embryo genital tubercle neural layer of retina spermatocyte yolk sac esophagus muscle of thigh ventricular zone granulocyte lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding SNARE binding zinc ion binding metal ion binding Cellular component cytoplasm endoplasmic reticulum membrane membrane Golgi membrane endoplasmic reticulum COPII vesicle coat cytosol ER to Golgi transport vesicle membrane cytoplasmic vesicle Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I COPII vesicle coating protein transport intracellular protein transport vesicle-mediated transport in utero embryonic development endoplasmic reticulum to Golgi vesicle-mediated transport COPII-coated vesicle cargo loading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9632 218811 Ensembl ENSG00000176986 ENSMUSG00000039367 UniProt P53992 n/a RefSeq (mRNA) NM_004922 NM_198597 NM_001168273 NM_172596 RefSeq (protein) NP_004913 NP_940999 n/a Location (UCSC) Chr 10: 73.74 – 73.77 Mb Chr 14: 20.72 – 20.74 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.^[7]

Interactions

SEC24C has been shown to interact with SEC23A.^[8]