SEC24D

Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene.^[5][6][7]

SEC24D
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3EFO, 3EG9
Identifiers
Aliases	SEC24D, CLCRP2, SEC24 homolog D, COPII coat complex component
External IDs	OMIM: 607186; MGI: 1916858; HomoloGene: 40986; GeneCards: SEC24D; OMA:SEC24D - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q26 Start 118,722,823 bp[1] End 118,838,683 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 123,061,104 bp[2] End 123,159,290 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium jejunal mucosa islet of Langerhans ascending aorta right coronary artery Descending thoracic aorta right lobe of liver smooth muscle tissue body of pancreas tibia Top expressed in yolk sac calvaria ascending aorta aortic valve seminal vesicula duodenum epithelium of small intestine islet of Langerhans jejunum umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding SNARE binding zinc ion binding metal ion binding Cellular component cytoplasm endoplasmic reticulum membrane membrane Golgi membrane endoplasmic reticulum COPII vesicle coat cytosol ER to Golgi transport vesicle membrane cytoplasmic vesicle Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I in utero embryonic development COPII vesicle coating protein transport intracellular protein transport vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport COPII-coated vesicle cargo loading Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9871 69608 Ensembl ENSG00000150961 ENSMUSG00000039234 UniProt O94855 n/a RefSeq (mRNA) NM_014822 NM_001318066 NM_027135 RefSeq (protein) NP_001304995 NP_055637 n/a Location (UCSC) Chr 4: 118.72 – 118.84 Mb Chr 3: 123.06 – 123.16 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.^[7]