SEC61B

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.^[5][6][7]

SEC61B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWB, 4CG6
Identifiers
Aliases	SEC61B, Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDs	OMIM: 609214; MGI: 1913462; HomoloGene: 38229; GeneCards: SEC61B; OMA:SEC61B - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.33 Start 99,222,064 bp[1] End 99,230,615 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 47,474,658 bp[2] End 47,483,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland body of pancreas oocyte corpus epididymis pylorus anterior pituitary trachea olfactory zone of nasal mucosa beta cell right lobe of liver Top expressed in parotid gland seminal vesicula submandibular gland gastrula islet of Langerhans mandibular prominence molar maxillary prominence somite lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function epidermal growth factor binding protein binding RNA binding protein-transporting ATPase activity Cellular component integral component of membrane cytosol membrane Sec61 endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum Sec complex Biological process retrograde protein transport, ER to cytosol IRE1-mediated unfolded protein response ubiquitin-dependent ERAD pathway protein transport intracellular protein transport SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane, translocation transport regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10952 66212 Ensembl ENSG00000106803 ENSMUSG00000053317 UniProt P60468 Q9CQS8 RefSeq (mRNA) NM_006808 NM_024171 RefSeq (protein) NP_006799 NP_077133 Location (UCSC) Chr 9: 99.22 – 99.23 Mb Chr 4: 47.47 – 47.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.^[7]