SECISBP2

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.^[5][6]

SECISBP2
Identifiers
Aliases	SECISBP2, SBP2, SECIS binding protein 2
External IDs	OMIM: 607693; MGI: 1922670; HomoloGene: 11415; GeneCards: SECISBP2; OMA:SECISBP2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.2 Start 89,318,500 bp[1] End 89,359,663 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A5 Start 51,805,733 bp[2] End 51,838,080 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sperm body of pancreas left ovary right uterine tube right ovary left testis right testis sural nerve body of uterus Top expressed in hand Rostral migratory stream otolith organ utricle mesenteric lymph nodes primitive streak zygote hair follicle bone marrow secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mRNA 3'-UTR binding protein binding RNA binding selenocysteine insertion sequence binding ribonucleoprotein complex binding Cellular component nucleus mitochondrion ribonucleoprotein complex Biological process protein biosynthesis striatum development neuron development negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay selenocysteine incorporation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79048 75420 Ensembl ENSG00000187742 ENSMUSG00000035139 UniProt Q96T21 n/a RefSeq (mRNA) NM_001282688 NM_001282689 NM_001282690 NM_024077 NM_001354696 NM_001354697 NM_001354698 NM_001354702 NM_029279 NM_001308448 RefSeq (protein) NP_001269617 NP_001269618 NP_001269619 NP_076982 NP_001341625 NP_001341626 NP_001341627 NP_001341631 n/a Location (UCSC) Chr 9: 89.32 – 89.36 Mb Chr 13: 51.81 – 51.84 Mb PubMed search [3] [4]
Wikidata
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Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.^[6]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.^[6]

See also

• Thyroid hormone resistance