SELT

For the airport with that ICAO code, see Cotopaxi International Airport.

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.^[5][6][7]

SELENOT
Identifiers
Aliases	SELENOT, SELT, selenoprotein T
External IDs	OMIM: 607912; MGI: 1916477; HomoloGene: 32304; GeneCards: SELENOT; OMA:SELENOT - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 150,602,875 bp[1] End 150,630,436 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 D Start 58,484,057 bp[2] End 58,500,554 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans right adrenal gland right adrenal cortex internal globus pallidus left adrenal gland monocyte beta cell stromal cell of endometrium left adrenal cortex prefrontal cortex Top expressed in olfactory epithelium iris median eminence sciatic nerve primitive streak Epithelium of choroid plexus barrel cortex Region I of hippocampus proper vestibular membrane of cochlear duct endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function selenium binding thioredoxin-disulfide reductase activity oxidoreductase activity Cellular component endoplasmic reticulum endoplasmic reticulum membrane membrane integral component of membrane Biological process selenocysteine incorporation positive regulation of cytosolic calcium ion concentration positive regulation of growth hormone secretion cellular oxidant detoxification response to glucose pancreas development insulin secretion involved in cellular response to glucose stimulus glucose homeostasis cell redox homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51714 69227 Ensembl ENSG00000198843 ENSMUSG00000075700 UniProt P62341 P62342 RefSeq (mRNA) NM_016275 NM_001040396 NM_026997 RefSeq (protein) NP_057359 NP_001035486 Location (UCSC) Chr 3: 150.6 – 150.63 Mb Chr 3: 58.48 – 58.5 Mb PubMed search [3] [4]
Wikidata
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Gene

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.^[7]

Protein structure

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

See also

• selenoprotein