SEMA3B

Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.^[5][6][7]

SEMA3B
Identifiers
Aliases	SEMA3B, LUCA-1, SEMA5, SEMAA, SemA, semaV, semaphorin 3B
External IDs	OMIM: 601281; MGI: 107561; HomoloGene: 20972; GeneCards: SEMA3B; OMA:SEMA3B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,267,558 bp[1] End 50,277,546 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.31 cM Start 107,474,873 bp[2] End 107,486,428 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve right adrenal gland left adrenal cortex right adrenal cortex C1 segment sural nerve middle frontal gyrus trigeminal ganglion olfactory bulb optic nerve Top expressed in sciatic nerve choroid plexus of fourth ventricle Epithelium of choroid plexus calvaria utricle ankle joint right kidney retinal pigment epithelium iris lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component extracellular region endoplasmic reticulum extracellular space integral component of plasma membrane collagen-containing extracellular matrix Biological process axon guidance cell-cell signaling negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance chemorepulsion of axon semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7869 20347 Ensembl ENSG00000012171 ENSMUSG00000057969 UniProt Q13214 Q62177 RefSeq (mRNA) NM_001005914 NM_001290060 NM_001290061 NM_001290062 NM_001290063 NM_004636 NM_001042779 NM_001291537 NM_001291538 NM_001291539 NM_009153 RefSeq (protein) NP_001005914 NP_001276989 NP_001276990 NP_001276991 NP_001276992 NP_004627 n/a Location (UCSC) Chr 3: 50.27 – 50.28 Mb Chr 9: 107.47 – 107.49 Mb PubMed search [3] [4]
Wikidata
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Function

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.^[7]