SEMA4A

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.^[5][6]

SEMA4A
Identifiers
Aliases	SEMA4A, CORD10, RP35, SEMAB, SEMB, semaphorin 4A
External IDs	OMIM: 607292; MGI: 107560; HomoloGene: 8425; GeneCards: SEMA4A; OMA:SEMA4A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q22 Start 156,147,366 bp[1] End 156,177,752 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 88,343,266 bp[2] End 88,368,489 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte bone marrow cells blood Amygdala nucleus accumbens skin of abdomen left lobe of thyroid gland retinal pigment epithelium cingulate gyrus Top expressed in granulocyte Paneth cell retinal pigment epithelium ventromedial nucleus jejunum paraventricular nucleus of hypothalamus arcuate nucleus prostate ileum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane nucleus cytosol intracellular membrane-bounded organelle plasma membrane extracellular space membrane integral component of plasma membrane Biological process cell differentiation adaptive immune response axonogenesis immune system process T-helper 1 cell differentiation nervous system development multicellular organism development angiogenesis regulation of endothelial cell migration regulation of cell shape negative regulation of angiogenesis T cell differentiation involved in immune response semaphorin-plexin signaling pathway negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance positive regulation of excitatory synapse assembly positive regulation of inhibitory synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64218 20351 Ensembl ENSG00000196189 ENSMUSG00000028064 UniProt Q9H3S1 Q62178 RefSeq (mRNA) NM_001193300 NM_001193301 NM_001193302 NM_022367 NM_001370567 NM_001370568 NM_001370569 NM_001370571 NM_001163489 NM_001163490 NM_001163491 NM_013658 RefSeq (protein) NP_001180229 NP_001180230 NP_001180231 NP_071762 NP_001357496 NP_001357497 NP_001357498 NP_001357500 NP_001156961 NP_001156962 NP_001156963 NP_038686 Location (UCSC) Chr 1: 156.15 – 156.18 Mb Chr 3: 88.34 – 88.37 Mb PubMed search [3] [4]
Wikidata
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Function

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM]^[6]

Clinical significance

A germline variant in SEMA4A (V78M) has been demonstrated to confer risk for colorectal cancer type X.^[7]

Recently it has been identified as a novel therapeutic target in Multiple myeloma.^[8]