SEMA5A

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.^[5][6][7]

SEMA5A
Identifiers
Aliases	SEMA5A, SEMAF, semF, semaphorin 5A
External IDs	OMIM: 609297; MGI: 107556; HomoloGene: 2949; GeneCards: SEMA5A; OMA:SEMA5A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.31 Start 9,035,033 bp[1] End 9,546,075 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 13.02 cM Start 32,244,956 bp[2] End 32,696,487 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in metanephric glomerulus stromal cell of endometrium periodontal fiber synovial joint nipple olfactory bulb sural nerve parietal pleura trigeminal ganglion decidua Top expressed in molar internal carotid artery lateral septal nucleus vas deferens lateral geniculate nucleus external carotid artery medial geniculate nucleus human fetus ventricular zone ventromedial nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chondroitin sulfate proteoglycan binding heparan sulfate proteoglycan binding syndecan binding semaphorin receptor binding neuropilin binding chemorepellent activity Cellular component membrane plasma membrane extracellular exosome integral component of membrane extracellular space Biological process negative regulation of endothelial cell apoptotic process negative regulation of cell adhesion cell differentiation positive regulation of protein kinase B signaling positive regulation of endothelial cell proliferation positive regulation of endothelial cell chemotaxis cell-cell signaling positive regulation of axon extension involved in axon guidance blood vessel endothelial cell proliferation involved in sprouting angiogenesis nervous system development positive regulation of angiogenesis multicellular organism development diencephalon development cell adhesion signal clustering cell chemotaxis positive chemotaxis axonal fasciculation positive regulation of actin filament depolymerization negative regulation of axon extension involved in axon guidance negative chemotaxis neural crest cell migration positive regulation of cell migration semaphorin-plexin signaling pathway positive regulation of canonical Wnt signaling pathway axon extension neuron projection guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9037 20356 Ensembl ENSG00000112902 ENSMUSG00000022231 UniProt Q13591 Q62217 Q3UPZ0 RefSeq (mRNA) NM_003966 NM_009154 RefSeq (protein) NP_003957 NP_033180 Location (UCSC) Chr 5: 9.04 – 9.55 Mb Chr 15: 32.24 – 32.7 Mb PubMed search [3] [4]
Wikidata
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Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development.^[7][5]

Semaphorin 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions.^[8][9]