SEMA6A

Semaphorin-6A is a protein that in humans is encoded by the SEMA6A gene.^[5][6][7]

SEMA6A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3AFC, 3AL8, 3OKW, 3OKY
Identifiers
Aliases	SEMA6A, HT018, SEMA, SEMA6A1, SEMAQ, VIA, semaphorin 6A
External IDs	OMIM: 605885; MGI: 1203727; HomoloGene: 32426; GeneCards: SEMA6A; OMA:SEMA6A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q23.1 Start 116,443,555 bp[1] End 116,574,823 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 C Start 47,368,665 bp[2] End 47,501,937 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve external globus pallidus subthalamic nucleus corpus callosum jejunal mucosa lateral nuclear group of thalamus pars reticulata ventral tegmental area superior vestibular nucleus pons Top expressed in tail of embryo genital tubercle lumbar subsegment of spinal cord yolk sac Dermatocranium membranous bone epiblast mandible cartilage of the septum medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane axon plasma membrane membrane integral component of plasma membrane extracellular space Biological process animal organ morphogenesis multicellular organism development cell surface receptor signaling pathway cell differentiation cytoskeleton organization nervous system development apoptotic process axon guidance positive regulation of neuron migration negative regulation of sprouting angiogenesis negative regulation of angiogenesis negative regulation of cell adhesion involved in sprouting angiogenesis cellular response to vascular endothelial growth factor stimulus negative regulation of ERK1 and ERK2 cascade negative regulation of vascular endothelial growth factor signaling pathway neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance negative chemotaxis semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57556 20358 Ensembl ENSG00000092421 ENSMUSG00000019647 UniProt Q9H2E6 O35464 RefSeq (mRNA) NM_001300780 NM_020681 NM_020796 NM_018744 NM_001311097 RefSeq (protein) NP_001287709 NP_065847 NP_001298026 NP_061214 Location (UCSC) Chr 5: 116.44 – 116.57 Mb Chr 18: 47.37 – 47.5 Mb PubMed search [3] [4]
Wikidata
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In melanocytic cells SEMA6A gene expression may be regulated by MITF.^[8]