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SENP8

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

SENP8
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Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.[5][6][7]

Quick Facts Available structures, PDB ...

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003).[supplied by OMIM][7]

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