SEPSECS

O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.^{[5][6][7][8][9]}

SEPSECS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HL2, 4ZDO, 4ZDL, 4ZDP
Identifiers
Aliases	SEPSECS, LP, PCH2D, SLA, SLA/LP, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, soluble liver antigen, SecS
External IDs	OMIM: 613009; MGI: 1098791; HomoloGene: 15031; GeneCards: SEPSECS; OMA:SEPSECS - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 25,120,014 bp[1] End 25,160,550 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 28.44 cM Start 52,797,429 bp[2] End 52,827,050 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum testicle right lobe of liver jejunal mucosa gonad Achilles tendon body of pancreas pancreatic epithelial cell rectum gastric mucosa Top expressed in muscle of thorax islet of Langerhans left lobe of liver thyroid cartilage spermatocyte secondary oocyte right kidney renal pelvis Ileal epithelium zygote More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity tRNA binding selenotransferase activity catalytic activity protein binding RNA binding phosphoseryl-selenocysteinyl-tRNA selenium transferase activity Cellular component cytoplasm cytosol nucleus Biological process selenocysteine incorporation protein biosynthesis selenocysteine metabolic process selenocysteinyl-tRNA(Sec) biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51091 211006 Ensembl ENSG00000109618 ENSMUSG00000029173 UniProt Q9HD40 Q6P6M7 RefSeq (mRNA) NM_001159728 NM_016955 NM_172490 NM_001363463 RefSeq (protein) NP_058651 NP_766078 NP_001350392 Location (UCSC) Chr 4: 25.12 – 25.16 Mb Chr 5: 52.8 – 52.83 Mb PubMed search [3] [4]
Wikidata
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