SEPT12

Septin 12 is a protein that in humans is encoded by the SEPT12 gene.^[5]

SEPTIN12
Identifiers
Aliases	SEPTIN12, SPGF10, septin 12, SEPT12
External IDs	OMIM: 611562; MGI: 1918339; HomoloGene: 69435; GeneCards: SEPTIN12; OMA:SEPTIN12 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 4,777,606 bp[1] End 4,788,398 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 4,804,722 bp[2] End 4,815,716 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis testicle cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum primary visual cortex C1 segment medulla oblongata mucosa of transverse colon Top expressed in seminiferous tubule spermatocyte spermatid blastocyst morula secondary oocyte gastrula zygote primary oocyte mucosa of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding phosphatidylinositol binding protein homodimerization activity GDP binding identical protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm microtubule cytoskeleton perinuclear region of cytoplasm sperm annulus spindle cell projection midbody cleavage furrow motile cilium cytoskeleton cilium stress fiber septin complex nucleus septin ring septin filament array Biological process cell cycle cell division sperm motility spermatogenesis cell differentiation flagellated sperm motility mitotic cytokinesis septin ring assembly cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 124404 71089 Ensembl ENSG00000140623 ENSMUSG00000022542 UniProt Q8IYM1 n/a RefSeq (mRNA) NM_001154458 NM_144605 NM_027669 NM_029374 NM_001373945 RefSeq (protein) NP_001147930 NP_653206 n/a Location (UCSC) Chr 16: 4.78 – 4.79 Mb Chr 16: 4.8 – 4.82 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]