SEPT4

Septin-4 is a protein that in humans is encoded by the SEPT4 gene.^[5][6]

SEPT4
Identifiers
Aliases	SEPT4, ARTS, BRADEION, CE5B3, H5, MART, PNUTL2, SEP4, hCDCREL-2, hucep-7, septin 4, Sept4
External IDs	OMIM: 603696; MGI: 1270156; HomoloGene: 6107; GeneCards: SEPT4; OMA:SEPT4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 58,520,250 bp[1] End 58,540,818 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 87,457,479 bp[2] End 87,481,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right hemisphere of cerebellum middle frontal gyrus paraflocculus of cerebellum corpus callosum external globus pallidus right frontal lobe internal globus pallidus putamen inferior ganglion of vagus nerve Top expressed in lobe of cerebellum cerebellar vermis deep cerebellar nuclei lateral geniculate nucleus globus pallidus anterior horn of spinal cord neural layer of retina central gray substance of midbrain superior colliculus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding structural molecule activity protein binding magnesium ion binding GTPase activity GTP binding protein homodimerization activity molecular adaptor activity Cellular component cytoplasm cell projection myelin sheath sperm flagellum nucleoplasm mitochondrion motile cilium cytoskeleton nucleus sperm annulus septin complex cilium septin ring synaptic vesicle microtubule cytoskeleton septin filament array mitochondrial outer membrane cytosol Biological process regulation of apoptotic process sperm mitochondrion organization cell division brain development spermatid development positive regulation of apoptotic process sperm capacitation cell cycle positive regulation of protein ubiquitination positive regulation of intrinsic apoptotic signaling pathway apoptotic process spermatogenesis cell differentiation protein homooligomerization mitotic cytokinesis septin ring assembly regulation of exocytosis cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5414 18952 Ensembl ENSG00000108387 ENSMUSG00000020486 UniProt O43236 P28661 RefSeq (mRNA) NM_001198713 NM_001256782 NM_001256822 NM_004574 NM_080415 NM_080416 NM_080417 NM_001284392 NM_001284394 NM_001284398 NM_011129 NM_001361936 NM_001368775 NM_001368776 NM_001368777 NM_001368778 NM_001368779 RefSeq (protein) NP_001185642 NP_001243711 NP_001243751 NP_004565 NP_536340 NP_536341 NP_001350732 NP_001033793 NP_001355700 NP_001355701 NP_001271321 NP_001271323 NP_001271327 NP_035259 NP_001348865 NP_001355704 NP_001355705 NP_001355706 NP_001355707 NP_001355708 Location (UCSC) Chr 17: 58.52 – 58.54 Mb Chr 11: 87.46 – 87.48 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. The protein encoded by this gene is thought to be part of a complex involved in cytokinesis. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[6]