SEPW1

Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.^[5][6]

SELENOW
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NPB
Identifiers
Aliases	SELENOW, selW, SEPW1, selenoprotein W, 1, selenoprotein W
External IDs	OMIM: 603235; MGI: 1100878; HomoloGene: 2263; GeneCards: SELENOW; OMA:SELENOW - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 47,778,677 bp[1] End 47,784,686 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A2 Start 15,651,133 bp[2] End 15,656,327 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart prefrontal cortex right frontal lobe amygdala hippocampus proper cingulate gyrus caudate nucleus anterior cingulate cortex nucleus accumbens inferior ganglion of vagus nerve Top expressed in saccule supraoptic nucleus triceps brachii muscle temporal lobe otic vesicle globus pallidus prefrontal cortex dentate gyrus aortic valve dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function antioxidant activity Cellular component cytoplasm cytosol Biological process cellular oxidant detoxification response to selenium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6415 20364 Ensembl ENSG00000178980 ENSMUSG00000041571 UniProt P63302 P63300 RefSeq (mRNA) NM_003009 NM_009156 RefSeq (protein) NP_003000 NP_033182 Location (UCSC) Chr 19: 47.78 – 47.78 Mb Chr 7: 15.65 – 15.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein shows highest expression in skeletal muscle and heart, and may be involved in oxidation-reduction reactions. A retroprocessed pseudogene, SEPW1P, has been identified and mapped to chromosome 1p35-34.^[6]