SERINC3

Serine incorporator 3 is a protein that in humans is encoded by the SERINC3 gene.^[5][6] It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. ^[7][8][9]

SERINC3
Identifiers
Aliases	SERINC3, AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1, serine incorporator 3
External IDs	OMIM: 607165; MGI: 1349457; HomoloGene: 38230; GeneCards: SERINC3; OMA:SERINC3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,496,221 bp[1] End 44,522,085 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 163,465,192 bp[2] End 163,487,051 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell tendon of biceps brachii Pons internal globus pallidus Brodmann area 23 middle temporal gyrus superior frontal gyrus stromal cell of endometrium postcentral gyrus prefrontal cortex Top expressed in lobe of prostate seminal vesicula stroma of bone marrow left lung lobe blood Paneth cell median eminence parotid gland Gonadal ridge crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function L-serine transmembrane transporter activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane cytoplasm perinuclear region of cytoplasm plasma membrane Biological process phosphatidylserine metabolic process detection of virus innate immune response defense response to virus positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway sphingolipid metabolic process L-serine transport immune system process L-serine biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10955 26943 Ensembl ENSG00000132824 ENSMUSG00000017707 UniProt Q13530 Q9QZI9 RefSeq (mRNA) NM_198941 NM_006811 NM_012032 RefSeq (protein) NP_006802 NP_945179 NP_036162 Location (UCSC) Chr 20: 44.5 – 44.52 Mb Chr 2: 163.47 – 163.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse