SERPINA9

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.^[5] Serpin A9 is a member of the serpin family of serine protease inhibitors.

SERPINA9
Identifiers
Aliases	SERPINA9, GCET1, SERPINA11, SERPINA11b, serpin family A member 9
External IDs	OMIM: 615677; MGI: 1919157; HomoloGene: 23633; GeneCards: SERPINA9; OMA:SERPINA9 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.13 Start 94,462,717 bp[1] End 94,479,689 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 103,961,002 bp[2] End 103,980,014 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx testicle lymph node appendix superior surface of tongue oral cavity tonsil skin of abdomen skin of leg gonad Top expressed in striatum of neuraxis esophagus lip superior frontal gyrus exocrine gland liver visual cortex Cerebellum cerebellar cortex primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component extracellular region membrane cytoplasm extracellular space Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 327657 71907 Ensembl ENSG00000170054 ENSMUSG00000058260 UniProt Q86WD7 Q9D7D2 RefSeq (mRNA) NM_001042518 NM_001284275 NM_001284276 NM_175739 NM_027997 NM_001361910 NM_001361912 RefSeq (protein) NP_001035983 NP_001271204 NP_001271205 NP_783866 NP_082273 NP_001348839 NP_001348841 Location (UCSC) Chr 14: 94.46 – 94.48 Mb Chr 12: 103.96 – 103.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.^[6][7][8]