SERPINI2

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.^[5][6]

SERPINI2
Identifiers
Aliases	SERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2
External IDs	OMIM: 605587; MGI: 1915181; HomoloGene: 21248; GeneCards: SERPINI2; OMA:SERPINI2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.1 Start 167,441,914 bp[1] End 167,478,972 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E3 Start 75,149,677 bp[2] End 75,177,385 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas right uterine tube bronchial epithelial cell testicle islet of Langerhans olfactory zone of nasal mucosa pancreatic epithelial cell mucosa of paranasal sinus monocyte caudate nucleus Top expressed in pyloric antrum pancreas islet of Langerhans embryo embryo migratory enteric neural crest cell duodenum right ventricle lumbar subsegment of spinal cord spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protein binding serine-type endopeptidase inhibitor activity Cellular component extracellular region extracellular exosome extracellular space Biological process negative regulation of peptidase activity negative regulation of endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5276 67931 Ensembl ENSG00000114204 ENSMUSG00000034139 UniProt O75830 Q9JK88 RefSeq (mRNA) NM_006217 NM_001012303 NM_001394327 NM_026460 RefSeq (protein) NP_001012303 NP_006208 NP_080736 Location (UCSC) Chr 3: 167.44 – 167.48 Mb Chr 3: 75.15 – 75.18 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.^[6]