SESN1

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.^[5][6][7]

SESN1
Identifiers
Aliases	SESN1, PA26, SEST1, sestrin 1
External IDs	OMIM: 606103; MGI: 2155278; HomoloGene: 8697; GeneCards: SESN1; OMA:SESN1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 108,984,309 bp[1] End 109,094,846 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 22.77 cM Start 41,685,931 bp[2] End 41,784,420 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis muscle of thigh thoracic diaphragm glutes gastrocnemius muscle muscle of arm biceps brachii Skeletal muscle tissue of biceps brachii triceps brachii muscle right ovary Top expressed in myocardium of ventricle intercostal muscle conjunctival fornix ciliary body cerebellar vermis interventricular septum iris lobe of cerebellum retinal pigment epithelium vestibular membrane of cochlear duct More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity peroxiredoxin activity protein binding leucine binding oxidoreductase activity, acting on peroxide as acceptor Cellular component cytosol cytoplasm GATOR2 complex nucleus fibrillar center TORC2 complex Biological process regulation of response to reactive oxygen species reactive oxygen species metabolic process cellular oxidant detoxification negative regulation of TORC1 signaling cellular response to amino acid starvation cellular response to glucose starvation positive regulation of macroautophagy cellular response to amino acid stimulus cellular response to leucine cellular response to leucine starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27244 140742 Ensembl ENSG00000080546 ENSMUSG00000038332 UniProt Q9Y6P5 P58006 RefSeq (mRNA) NM_014454 NM_001199933 NM_001199934 NM_001013370 NM_001162908 RefSeq (protein) NP_001186862 NP_001186863 NP_055269 NP_001013388 NP_001156380 Location (UCSC) Chr 6: 108.98 – 109.09 Mb Chr 10: 41.69 – 41.78 Mb PubMed search [3] [4]
Wikidata
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See also

• SESN2