SF3A2

Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene.^[5][6][7]

SF3A2
Identifiers
Aliases	SF3A2, PRP11, PRPF11, SAP62, SF3a66, splicing factor 3a subunit 2
External IDs	OMIM: 600796; MGI: 104912; HomoloGene: 136815; GeneCards: SF3A2; OMA:SF3A2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,236,824 bp[1] End 2,248,655 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,634,032 bp[2] End 80,640,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis left ovary right testis right uterine tube right ovary body of uterus granulocyte canal of the cervix skin of leg skin of abdomen Top expressed in internal carotid artery external carotid artery Ileal epithelium Paneth cell lactiferous gland condyle somite trigeminal ganglion fossa hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding zinc ion binding protein binding metal ion binding RNA binding Cellular component nuclear speck catalytic step 2 spliceosome spliceosomal complex small nuclear ribonucleoprotein complex U2-type prespliceosome nucleus U2 snRNP nucleoplasm U2-type precatalytic spliceosome Biological process mRNA splicing, via spliceosome mRNA processing mRNA 3'-splice site recognition RNA splicing positive regulation of neuron projection development spliceosomal complex assembly U2-type prespliceosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8175 20222 Ensembl ENSG00000104897 ENSMUSG00000020211 UniProt Q15428 Q62203 RefSeq (mRNA) NM_007165 NM_013651 RefSeq (protein) NP_009096 n/a Location (UCSC) Chr 19: 2.24 – 2.25 Mb Chr 10: 80.63 – 80.64 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.^[7]

Interactions

SF3A2 has been shown to interact with DDX46.^[8]