SFRS6

Splicing factor, arginine/serine-rich 6 is a protein that in humans is encoded by the SFRS6 gene.^[5][6]

SRSF6
Identifiers
Aliases	SRSF6, B52, HEL-S-91, SFRS6, SRP55, serine/arginine-rich splicing factor 6, serine and arginine rich splicing factor 6
External IDs	OMIM: 601944; MGI: 1915246; HomoloGene: 110783; GeneCards: SRSF6; OMA:SRSF6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.11 Start 43,457,893 bp[1] End 43,466,046 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H2|2 83.87 cM Start 162,773,448 bp[2] End 162,779,041 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube body of pancreas right lobe of thyroid gland right adrenal cortex right ovary left lobe of thyroid gland left ovary germinal epithelium ventricular zone left adrenal gland Top expressed in medullary collecting duct abdominal wall renal corpuscle endocardial cushion somite superior cervical ganglion epiblast ventricular zone dermis Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding nucleic acid binding pre-mRNA binding Cellular component nuclear speck nucleus nucleoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription negative regulation of keratinocyte differentiation positive regulation of epithelial cell proliferation involved in lung morphogenesis mRNA processing negative regulation of cell death regulation of alternative mRNA splicing, via spliceosome mRNA export from nucleus negative regulation of mRNA splicing, via spliceosome regulation of wound healing mRNA splice site selection regulation of keratinocyte proliferation alternative mRNA splicing, via spliceosome mRNA 3'-end processing negative regulation of gene expression RNA splicing response to insulin RNA export from nucleus negative regulation of type B pancreatic cell apoptotic process mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6431 67996 Ensembl ENSG00000124193 ENSMUSG00000016921 UniProt Q13247 Q3TWW8 RefSeq (mRNA) NM_006275 NM_026499 RefSeq (protein) NP_006266 NP_080775 Location (UCSC) Chr 20: 43.46 – 43.47 Mb Chr 2: 162.77 – 162.78 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is involved in mRNA splicing and may play a role in site selection in alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.^[6]