SFRS7

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a protein that in humans is encoded by the SRSF7 gene.^[5]

SRSF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HVZ
Identifiers
Aliases	SRSF7, 9G8, AAG3, SFRS7, serine/arginine-rich splicing factor 7, serine and arginine rich splicing factor 7
External IDs	OMIM: 600572; MGI: 1926232; HomoloGene: 134446; GeneCards: SRSF7; OMA:SRSF7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p22.1 Start 38,743,599 bp[1] End 38,751,494 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E3 Start 80,507,509 bp[2] End 80,514,736 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence granulocyte ventricular zone left uterine tube lymph node gastric mucosa peritoneum monocyte gonad appendix Top expressed in genital tubercle abdominal wall maxillary prominence mandibular prominence medullary collecting duct tail of embryo superior cervical ganglion medial ganglionic eminence vas deferens Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding protein binding nucleic acid binding RNA binding protein domain specific binding Cellular component cytoplasm nucleoplasm extracellular exosome nucleus nuclear speck Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA transport mRNA processing mRNA export from nucleus negative regulation of mRNA splicing, via spliceosome mRNA 3'-end processing RNA export from nucleus RNA splicing cellular response to leukemia inhibitory factor transport regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6432 225027 Ensembl ENSG00000115875 ENSMUSG00000024097 UniProt Q16629 Q8BL97 RefSeq (mRNA) NM_001031684 NM_001195446 NM_006276 NM_001363802 NM_001195485 NM_001195486 NM_001195487 NM_146083 NM_001360435 RefSeq (protein) NP_001026854 NP_001182375 NP_001350731 NP_001182414 NP_001182415 NP_001182416 NP_666195 NP_001347364 Location (UCSC) Chr 2: 38.74 – 38.75 Mb Chr 17: 80.51 – 80.51 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.^[5]