SFXN1

Sideroflexin-1 is a protein that in humans is encoded by the SFXN1 gene.^[5] According to Nora Kory et al., SFXN1 gene product has mitochondrial serine transporter activity.^[6]

SFXN1
Identifiers
Aliases	SFXN1, TCC, sideroflexin 1, SLC56A1
External IDs	OMIM: 615569; MGI: 2137677; HomoloGene: 41494; GeneCards: SFXN1; OMA:SFXN1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 175,477,062 bp[1] End 175,529,742 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 28.4 cM Start 54,225,888 bp[2] End 54,262,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid buccal mucosa cell ventricular zone liver stromal cell of endometrium right lobe of liver ganglionic eminence kidney tubule endothelial cell tendon of biceps brachii Top expressed in tunica adventitia of aorta crypt of lieberkuhn of small intestine human kidney brown adipose tissue right kidney lacrimal gland white adipose tissue intestinal villus left lobe of liver parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion transmembrane transporter activity L-serine transmembrane transporter activity D-serine transmembrane transporter activity Cellular component integral component of membrane membrane mitochondrion mitochondrial membranes integral component of mitochondrial inner membrane mitochondrial inner membrane Biological process erythrocyte differentiation ion transmembrane transport iron ion homeostasis iron ion transport ion transport transmembrane transport one-carbon metabolic process L-serine transport D-serine transport serine import into mitochondrion amino acid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94081 14057 Ensembl ENSG00000164466 ENSMUSG00000021474 UniProt Q9H9B4 Q99JR1 RefSeq (mRNA) NM_022754 NM_001322977 NM_001322978 NM_001322980 NM_001322981 NM_001322982 NM_001322983 NM_027324 RefSeq (protein) NP_001309906 NP_001309907 NP_001309909 NP_001309910 NP_001309911 NP_001309912 NP_073591 NP_081600 Location (UCSC) Chr 5: 175.48 – 175.53 Mb Chr 13: 54.23 – 54.26 Mb PubMed search [3] [4]
Wikidata
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