SGIP1

SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene.^[5][6]

SGIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AWR, 5AWT, 5AWU, 5AWS
Identifiers
Aliases	SGIP1, SH3 domain GRB2 like endophilin interacting protein 1, SH3GL interacting endocytic adaptor 1
External IDs	OMIM: 611540; MGI: 1920344; HomoloGene: 13001; GeneCards: SGIP1; OMA:SGIP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 66,533,267 bp[1] End 66,751,139 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 102,741,297 bp[2] End 102,973,628 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium tibial arteries Descending thoracic aorta ascending aorta prefrontal cortex middle temporal gyrus Brodmann area 46 Brodmann area 23 endothelial cell C1 segment Top expressed in Rostral migratory stream neural layer of retina superior frontal gyrus substantia nigra dentate gyrus of hippocampal formation granule cell piriform cortex medial dorsal nucleus primary visual cortex cerebellar cortex medial geniculate nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding SH3 domain binding tubulin binding protein binding phospholipid binding cytoskeletal protein binding Cellular component cytoplasm plasma membrane clathrin-coated pit AP-2 adaptor complex membrane clathrin-coated vesicle cytosol cytoskeleton Biological process positive regulation of receptor-mediated endocytosis endocytosis plasma membrane tubulation membrane organization response to dietary excess positive regulation of feeding behavior clathrin-dependent endocytosis energy homeostasis clathrin coat assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84251 73094 Ensembl ENSG00000118473 ENSMUSG00000028524 UniProt Q9BQI5 Q8VD37 RefSeq (mRNA) NM_001308203 NM_032291 NM_001350217 NM_001350218 NM_001376534 NM_001376535 NM_001376536 NM_001376537 NM_001376538 NM_001376539 NM_001376540 NM_001376541 NM_001376542 NM_001376543 NM_001376544 NM_001376545 NM_001376546 NM_001376547 NM_001376548 NM_001376549 NM_001376550 NM_001376551 NM_001376552 NM_001376554 NM_001376555 NM_001376556 NM_001376557 NM_001285852 NM_001285859 NM_001285860 NM_001285862 NM_144906 RefSeq (protein) NP_001295132 NP_115667 NP_001337146 NP_001337147 NP_001363463 NP_001363464 NP_001363465 NP_001363466 NP_001363467 NP_001363468 NP_001363469 NP_001363470 NP_001363471 NP_001363472 NP_001363473 NP_001363474 NP_001363475 NP_001363476 NP_001363477 NP_001363478 NP_001363479 NP_001363480 NP_001363481 NP_001363483 NP_001363484 NP_001363485 NP_001363486 NP_001272781 NP_001272788 NP_001272789 NP_001272791 NP_659155 Location (UCSC) Chr 1: 66.53 – 66.75 Mb Chr 4: 102.74 – 102.97 Mb PubMed search [3] [4]
Wikidata
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