SGMS1

Phosphatidylcholine:ceramide cholinephosphotransferase 1 is an enzyme that in humans is encoded by the SGMS1 gene.^[5][6][7]

SGMS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8C
Identifiers
Aliases	SGMS1, MOB, MOB1, SMS1, TMEM23, hmob33, sphingomyelin synthase 1
External IDs	OMIM: 611573; MGI: 2444110; HomoloGene: 27040; GeneCards: SGMS1; OMA:SGMS1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.23 Start 50,305,586 bp[1] End 50,625,163 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 32,122,727 bp[2] End 32,389,714 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon palpebral conjunctiva retinal pigment epithelium Epithelium of choroid plexus germinal epithelium corpus callosum hair follicle skin of thigh C1 segment skin of hip Top expressed in spermatid seminiferous tubule retinal pigment epithelium Epithelium of choroid plexus sciatic nerve left lung lobe interventricular septum vestibular membrane of cochlear duct right lung lobe spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity ceramide cholinephosphotransferase activity sphingomyelin synthase activity ceramide phosphoethanolamine synthase activity Cellular component integral component of membrane integral component of Golgi membrane Golgi trans cisterna Golgi membrane plasma membrane Golgi apparatus endoplasmic reticulum nucleus membrane integral component of plasma membrane integral component of endoplasmic reticulum membrane Biological process lipid metabolism sphingomyelin biosynthetic process sphingolipid biosynthetic process phosphorylation apoptotic process sphingolipid metabolic process ceramide biosynthetic process regulation of intrinsic apoptotic signaling pathway inflammatory response positive regulation of gene expression cellular response to lipopolysaccharide cellular response to tumor necrosis factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259230 208449 Ensembl ENSG00000198964 ENSMUSG00000040451 UniProt Q86VZ5 Q8VCQ6 RefSeq (mRNA) NM_147156 NM_001168525 NM_001168526 NM_144792 NM_001362423 RefSeq (protein) NP_671512 NP_001161997 NP_001161998 NP_659041 NP_001349352 Location (UCSC) Chr 10: 50.31 – 50.63 Mb Chr 19: 32.12 – 32.39 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is predicted to be a five-pass transmembrane protein. This gene may be predominately expressed in brain.^[7]