SH2B2

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.^[5][6]

SH2B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q2H
Identifiers
Aliases	SH2B2, APS, SH2B adaptor protein 2
External IDs	OMIM: 605300; MGI: 1345171; HomoloGene: 10309; GeneCards: SH2B2; OMA:SH2B2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 102,285,091 bp[1] End 102,321,711 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,247,001 bp[2] End 136,275,410 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in triceps brachii muscle Skeletal muscle tissue of biceps brachii muscle of thigh vastus lateralis muscle renal medulla muscle of trunk Skeletal muscle tissue of rectus abdominis thoracic diaphragm tibialis anterior muscle body of tongue Top expressed in brown adipose tissue granulocyte white adipose tissue tunica adventitia of aorta spermatocyte ganglionic eminence internal carotid artery gastrula tail of embryo placenta More reference expression data BioGPS n/a
Gene ontology Molecular function JAK pathway signal transduction adaptor activity protein binding signaling adaptor activity transmembrane receptor protein tyrosine kinase adaptor activity identical protein binding Cellular component cytoplasm cytosol plasma membrane membrane stress fiber ruffle actin filament Biological process insulin receptor signaling pathway blood coagulation signal transduction regulation of receptor signaling pathway via JAK-STAT positive regulation of signal transduction intracellular signal transduction B-1 B cell homeostasis nervous system development cytokine-mediated signaling pathway regulation of metabolic process actin cytoskeleton organization regulation of Ras protein signal transduction regulation of immune response antigen receptor-mediated signaling pathway brown fat cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10603 23921 Ensembl ENSG00000160999 ENSMUSG00000005057 UniProt O14492 Q9JID9 RefSeq (mRNA) NM_020979 NM_001359228 NM_001359229 NM_001359230 NM_001359231 NM_018825 NM_001302938 NM_001302939 RefSeq (protein) NP_066189 NP_001346157 NP_001346158 NP_001346159 NP_001346160 NP_001289867 NP_001289868 NP_061295 Location (UCSC) Chr 7: 102.29 – 102.32 Mb Chr 5: 136.25 – 136.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.^[6]

Interactions

SH2B2 has been shown to interact with TrkA^[7] and Cbl gene.^[8][9]