SH2D1B

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.^[5][6][7]

SH2D1B
Identifiers
Aliases	SH2D1B, EAT2, SH2 domain containing 1B
External IDs	OMIM: 608510; MGI: 1349420; HomoloGene: 8070; GeneCards: SH2D1B; OMA:SH2D1B - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,395,268 bp[1] End 162,412,138 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,104,889 bp[2] End 170,114,338 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte gastrocnemius muscle blood testicle sperm muscle of thigh monocyte amniotic fluid deltoid muscle spleen Top expressed in spleen granulocyte lung jejunum bone marrow ileum choroid plexus prefrontal cortex medulla oblongata superior colliculus More reference expression data BioGPS n/a
Gene ontology Molecular function protein-macromolecule adaptor activity protein binding Cellular component cytosol intracellular anatomical structure Biological process innate immune response leukocyte activation involved in immune response adaptive immune response positive regulation of natural killer cell mediated immunity positive regulation of innate immune response regulation of immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 117157 26904 Ensembl ENSG00000198574 ENSMUSG00000102418 UniProt O14796 O35324 Q149T1 RefSeq (mRNA) NM_053282 NM_012009 RefSeq (protein) NP_444512 NP_036139 Location (UCSC) Chr 1: 162.4 – 162.41 Mb Chr 1: 170.1 – 170.11 Mb PubMed search [3] [4]
Wikidata
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By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM]^[7]

Interactions

SH2D1B has been shown to interact with SLAMF1.^[6]