SH2D3A

SH2 domain-containing protein 3A is a protein that in humans is encoded by the SH2D3A gene.^[3][4] The protein may be useful in Western Blots and ELISAs.^[5]

SH2D3A
Identifiers
Aliases	SH2D3A, NSP1, SH2 domain containing 3A
External IDs	OMIM: 604721; HomoloGene: 48351; GeneCards: SH2D3A; OMA:SH2D3A - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 6,752,160 bp[1] End 6,767,463 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell olfactory bulb mucosa of transverse colon skin of abdomen skin of leg granulocyte olfactory zone of nasal mucosa minor salivary glands body of pancreas tendon of biceps brachii n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding guanyl-nucleotide exchange factor activity Cellular component intracellular anatomical structure Biological process small GTPase mediated signal transduction JNK cascade positive regulation of signal transduction positive regulation of peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10045 n/a Ensembl ENSG00000125731 n/a UniProt Q9BRG2 n/a RefSeq (mRNA) NM_005490 n/a RefSeq (protein) NP_005481 n/a Location (UCSC) Chr 19: 6.75 – 6.77 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Interactions

SH2D3A has been shown to interact with the epidermal growth factor receptor.^[3] The gene may play a role in JNK activation.^[6]