SH3BP1

SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene.^[5][6][7]

SH3BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J9D, 4J9F
Identifiers
Aliases	SH3BP1, ARHGAP43, SH3 domain binding protein 1
External IDs	OMIM: 617368; MGI: 104603; HomoloGene: 7534; GeneCards: SH3BP1; OMA:SH3BP1 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,634,654 bp[1] End 37,656,117 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,783,968 bp[2] End 78,796,251 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte mucosa of transverse colon skin of abdomen spleen skin of leg rectum lymph node blood appendix Top expressed in granulocyte lip yolk sac esophagus mesenteric lymph nodes thymus superior frontal gyrus genital tubercle tail of embryo primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding protein binding GTPase activator activity semaphorin receptor binding Cellular component cytoplasm exocyst lamellipodium phagocytic cup nucleus cytosol adherens junction bicellular tight junction cell junction cell projection cell leading edge intracellular anatomical structure Biological process signal transduction phagocytosis, engulfment actin filament organization regulation of actin filament depolymerization regulation of actin cytoskeleton organization cell junction assembly regulation of blood vessel endothelial cell migration establishment of epithelial cell apical/basal polarity negative regulation of small GTPase mediated signal transduction semaphorin-plexin signaling pathway phagocytosis cell migration positive regulation of GTPase activity filopodium assembly ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23616 20401 Ensembl ENSG00000100092 ENSMUSG00000022436 UniProt Q9Y3L3 P55194 RefSeq (mRNA) NM_018957 NM_001350055 NM_009164 NM_001316684 NM_001316685 NM_001316686 RefSeq (protein) NP_061830 NP_001336984 NP_001303613 NP_001303614 NP_001303615 NP_033190 Location (UCSC) Chr 22: 37.63 – 37.66 Mb Chr 15: 78.78 – 78.8 Mb PubMed search [3] [4]
Wikidata
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