SH3BP5

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.^[5][6][7]

SH3BP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H3B
Identifiers
Aliases	SH3BP5, SAB, SH3BP-5, SH3 domain binding protein 5
External IDs	OMIM: 605612; MGI: 1344391; HomoloGene: 23450; GeneCards: SH3BP5; OMA:SH3BP5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 15,254,353 bp[1] End 15,341,368 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 31,081,837 bp[2] End 31,158,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell germinal epithelium trigeminal ganglion pericardium visceral pleura secondary oocyte adrenal cortex tendon of biceps brachii left adrenal cortex spinal ganglia Top expressed in stroma of bone marrow granulocyte endothelial cell of lymphatic vessel dentate gyrus of hippocampal formation granule cell barrel cortex sexually immature organism mesenteric lymph nodes endocardial cushion atrioventricular valve saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase inhibitor activity protein binding SH3 domain binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm mitochondrion nucleoplasm nuclear body cytoplasmic vesicle membrane membrane cytoplasmic vesicle Biological process signal transduction negative regulation of protein tyrosine kinase activity intracellular signal transduction negative regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9467 24056 Ensembl ENSG00000131370 ENSMUSG00000021892 UniProt O60239 Q9Z131 RefSeq (mRNA) NM_001018009 NM_004844 NM_011894 NM_001347585 RefSeq (protein) NP_001018009 NP_004835 NP_001334514 NP_036024 NP_001391515 NP_001391516 NP_001391517 NP_001391518 Location (UCSC) Chr 3: 15.25 – 15.34 Mb Chr 14: 31.08 – 31.16 Mb PubMed search [3] [4]
Wikidata
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Interactions

SH3BP5 has been shown to interact with Bruton's tyrosine kinase^[5][6] and MAPK8.^[8]