SHC3

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.^[5][6]

SHC3
Identifiers
Aliases	SHC3, N-Shc, NSHC, RAI, SHCC, SHC adaptor protein 3
External IDs	OMIM: 605263; MGI: 106179; HomoloGene: 7536; GeneCards: SHC3; OMA:SHC3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.1 Start 89,005,771 bp[1] End 89,178,818 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 26.12 cM Start 51,585,077 bp[2] End 51,723,523 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 middle temporal gyrus endothelial cell superior frontal gyrus postcentral gyrus entorhinal cortex primary visual cortex orbitofrontal cortex frontal pole dorsolateral prefrontal cortex Top expressed in dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord superior frontal gyrus superior surface of tongue gallbladder ventricular zone primary visual cortex secondary oocyte zygote morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding signal transducer activity protein binding phosphotyrosine residue binding Cellular component cytosol plasma membrane cellular component Biological process intracellular signal transduction epidermal growth factor receptor signaling pathway synaptic transmission, glutamatergic transmembrane receptor protein tyrosine kinase signaling pathway MAPK cascade central nervous system development learning or memory Ras protein signal transduction signal transduction axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53358 20418 Ensembl ENSG00000148082 ENSMUSG00000021448 UniProt Q92529 Q61120 RefSeq (mRNA) NM_016848 NM_009167 RefSeq (protein) NP_058544 NP_033193 Location (UCSC) Chr 9: 89.01 – 89.18 Mb Chr 13: 51.59 – 51.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SHC3 has been shown to interact with RICS^[7] and TrkB.^[8][9]