SHPRH

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.^[5][6]

SHPRH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M85, 4QN1
Identifiers
Aliases	SHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase, RAD5
External IDs	OMIM: 608048; MGI: 1917581; HomoloGene: 6489; GeneCards: SHPRH; OMA:SHPRH - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q24.3 Start 145,864,245 bp[1] End 145,964,423 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 11,025,171 bp[2] End 11,093,339 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon testicle pancreatic epithelial cell sural nerve retinal pigment epithelium germinal epithelium gonad tibia skin of thigh bone marrow cell Top expressed in secondary oocyte lobe of cerebellum cerebellar vermis primary oocyte zygote genital tubercle lumbar subsegment of spinal cord ganglionic eminence trigeminal ganglion ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding protein binding hydrolase activity ATP binding helicase activity metal ion binding ubiquitin-protein transferase activity ubiquitin protein ligase binding transferase activity ubiquitin protein ligase activity Cellular component nucleosome nucleus nucleoplasm Biological process nucleosome assembly protein polyubiquitination DNA repair cellular response to DNA damage stimulus protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 257218 268281 Ensembl ENSG00000146414 ENSMUSG00000090112 UniProt Q149N8 Q7TPQ3 RefSeq (mRNA) NM_001042683 NM_173082 NM_001370327 NM_001370328 NM_001077707 NM_001284354 NM_172937 RefSeq (protein) NP_001036148 NP_775105 NP_001357256 NP_001357257 NP_001071175 NP_001271283 NP_766525 Location (UCSC) Chr 6: 145.86 – 145.96 Mb Chr 10: 11.03 – 11.09 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]^[6] SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.^[7]