SIBLING proteins

The family of non-collagenous proteins known as SIBLING proteins, standing for small integrin-binding ligand, N-linked glycoprotein, are components of the extracellular matrix of bone and dentin. Evidence shows that these proteins play key roles in the mineralization of these tissues.^[1]

The following are categorized as SIBLING proteins:^[1][2]

1. osteopontin (OPN)
2. bone sialoprotein (BSP)
3. dentin matrix protein 1 (DMP1)
4. dentin sialophosphoprotein (DSPP)
5. matrix extracellular phosphoglycoprotein (MEPE)

The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23.^[3]