SIX5

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.^[5][6]

SIX5
Identifiers
Aliases	SIX5, BOR2, DMAHP, SIX homeobox 5
External IDs	OMIM: 600963; MGI: 106220; HomoloGene: 72248; GeneCards: SIX5; OMA:SIX5 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,764,785 bp[1] End 45,769,252 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.46 cM Start 18,828,519 bp[2] End 18,832,474 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cardiac muscle tissue of right atrium right uterine tube right ovary myocardium of left ventricle left ovary parotid gland canal of the cervix right coronary artery left uterine tube body of uterus Top expressed in ascending aorta genital tubercle aortic valve corneal stroma tail of embryo cardiac muscle tissue of left ventricle ventricular zone molar Gonadal ridge male urethra More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription cis-regulatory region binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus cytoplasm transcription regulator complex Biological process multicellular organism development negative regulation of cell population proliferation lens development in camera-type eye negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II spermatid development negative regulation of skeletal muscle satellite cell proliferation anatomical structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 147912 20475 Ensembl ENSG00000177045 ENSMUSG00000040841 UniProt Q8N196 P70178 RefSeq (mRNA) NM_175875 NM_011383 RefSeq (protein) NP_787071 NP_035513 Location (UCSC) Chr 19: 45.76 – 45.77 Mb Chr 7: 18.83 – 18.83 Mb PubMed search [3] [4]
Wikidata
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