SKAP2

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.^[5][6][7]

SKAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OMH
Identifiers
Aliases	SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP-HOM, SKAP55R, src kinase associated phosphoprotein 2
External IDs	OMIM: 605215; MGI: 1889206; HomoloGene: 2919; GeneCards: SKAP2; OMA:SKAP2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 26,667,068 bp[1] End 26,995,239 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B3 Start 51,834,402 bp[2] End 51,989,529 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte pericardium monocyte trabecular bone visceral pleura buccal mucosa cell bone marrow cells lower lobe of lung pylorus Top expressed in zygote granulocyte secondary oocyte stroma of bone marrow blood primary oocyte primitive streak ascending aorta mesenteric lymph nodes renal corpuscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component plasma membrane cytoplasm nucleoplasm cytosol Biological process immune response-activating signal transduction B cell activation signal transduction negative regulation of cell population proliferation positive regulation of signal transduction protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8935 54353 Ensembl ENSG00000005020 ENSMUSG00000059182 UniProt O75563 Q3UND0 RefSeq (mRNA) NM_003930 NM_001303468 NM_018773 RefSeq (protein) NP_001290397 NP_003921 NP_061243 Location (UCSC) Chr 7: 26.67 – 27 Mb Chr 6: 51.83 – 51.99 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.^[7] It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.^[8]