SKIL

For other uses, see Skil (disambiguation).

Ski-like protein is a protein that in humans is encoded by the SKIL gene.^[5][6]

SKIL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3EQ5
Identifiers
Aliases	SKIL, SNO, SnoA, SnoI, SnoN, SKI-like proto-oncogene, SKI like proto-oncogene
External IDs	OMIM: 165340; MGI: 106203; HomoloGene: 3948; GeneCards: SKIL; OMA:SKIL - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,357,678 bp[1] End 170,396,835 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 15.12 cM Start 31,149,207 bp[2] End 31,176,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii mucosa of paranasal sinus jejunal mucosa Achilles tendon Skeletal muscle tissue of biceps brachii visceral pleura epithelium of nasopharynx epithelium of colon endothelial cell superficial temporal artery Top expressed in molar cumulus cell external carotid artery pineal gland tunica media of zone of aorta ciliary body body of femur mesenteric lymph nodes internal carotid artery umbilical cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription corepressor activity protein domain specific binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding SMAD binding chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific protein-containing complex binding Cellular component cytoplasm PML body nucleoplasm acrosomal vesicle nucleus protein-containing complex Biological process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors response to cytokine lymphocyte homeostasis response to antibiotic negative regulation of transcription by RNA polymerase II blastocyst formation positive regulation of axonogenesis protein homotrimerization lens fiber cell differentiation positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage spermatogenesis protein heterotrimerization response to growth factor skeletal muscle tissue development negative regulation of BMP signaling pathway transforming growth factor beta receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway neuron development negative regulation of cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6498 20482 Ensembl ENSG00000136603 ENSMUSG00000027660 UniProt P12757 Q60665 RefSeq (mRNA) NM_001145097 NM_001145098 NM_001248008 NM_005414 NM_001039090 NM_001271772 NM_011386 NM_001398558 NM_001398559 NM_001398560 RefSeq (protein) NP_001138569 NP_001138570 NP_001234937 NP_005405 NP_001034179 NP_001258701 NP_035516 NP_001385487 NP_001385488 NP_001385489 Location (UCSC) Chr 3: 170.36 – 170.4 Mb Chr 3: 31.15 – 31.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SKIL interacts with SKI protein,^[7] Mothers against decapentaplegic homolog 3^[8][9] and Mothers against decapentaplegic homolog 2.^[8][9]

Protein Family

SKIL belongs to the Ski/Sno/Dac family, shared by SKI protein, Dachshund, and SKIDA1.^[10] Members of the Ski/Sno/Dac family share a domain that is roughly 100 amino acids long.