SLC13A3

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.^[5][6][7]

SLC13A3
Identifiers
Aliases	SLC13A3, NADC3, SDCT2, solute carrier family 13 member 3, ARLIAK
External IDs	OMIM: 606411; MGI: 2149635; HomoloGene: 11266; GeneCards: SLC13A3; OMA:SLC13A3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,557,823 bp[1] End 46,684,467 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 165,246,948 bp[2] End 165,315,150 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule metanephric glomerulus oocyte secondary oocyte olfactory bulb human kidney C1 segment corpus callosum right lobe of liver placenta Top expressed in median eminence retinal pigment epithelium human kidney right kidney Rostral migratory stream proximal tubule pontine nuclei mammillary body olfactory tubercle arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity symporter activity succinate transmembrane transporter activity sodium:dicarboxylate symporter activity citrate transmembrane transporter activity high-affinity sodium:dicarboxylate symporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular exosome Biological process dicarboxylic acid transport sodium ion transport ion transport succinate transmembrane transport citrate transport transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64849 114644 Ensembl ENSG00000158296 ENSMUSG00000018459 UniProt Q8WWT9 Q91Y63 RefSeq (mRNA) NM_022829 NM_001011554 NM_001193339 NM_001193340 NM_001193342 NM_054055 RefSeq (protein) NP_001011554 NP_001180268 NP_001180269 NP_001180271 NP_073740 NP_473396 Location (UCSC) Chr 20: 46.56 – 46.68 Mb Chr 2: 165.25 – 165.32 Mb PubMed search [3] [4]
Wikidata
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Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.^[7]

See also

• Solute carrier family