SLC20A2

Sodium-dependent phosphate transporter 2 is a protein that in humans is encoded by the SLC20A2 gene.^[5][6][7]

SLC20A2
Identifiers
Aliases	SLC20A2, GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1, Ram-1, solute carrier family 20 member 2, IBGC2
External IDs	OMIM: 158378; MGI: 97851; HomoloGene: 68531; GeneCards: SLC20A2; OMA:SLC20A2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.21 Start 42,416,475 bp[1] End 42,541,926 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 11.42 cM Start 22,966,804 bp[2] End 23,059,628 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left lobe of thyroid gland right lobe of thyroid gland popliteal artery muscle of thigh tibial arteries right auricle of heart vena cava corpus callosum olfactory zone of nasal mucosa C1 segment Top expressed in molar interventricular septum extraocular muscle masseter muscle retinal pigment epithelium lens iris myocardium of ventricle muscle of thigh digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium:phosphate symporter activity symporter activity virus receptor activity inorganic phosphate transmembrane transporter activity sodium:inorganic phosphate symporter activity signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process sodium ion transport viral entry into host cell phosphate ion transport viral process ion transport sodium ion transmembrane transport transmembrane transport phosphate ion transmembrane transport sodium-dependent phosphate transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6575 20516 Ensembl ENSG00000168575 ENSMUSG00000037656 UniProt Q08357 Q80UP8 RefSeq (mRNA) NM_001257180 NM_001257181 NM_006749 NM_011394 RefSeq (protein) NP_001244109 NP_001244110 NP_006740 NP_035524 Location (UCSC) Chr 8: 42.42 – 42.54 Mb Chr 8: 22.97 – 23.06 Mb PubMed search [3] [4]
Wikidata
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Genomics

This gene is found on the short arm of chromosome 8 (8p12-p11) on the minus (Crick) strand. It is 123,077 bases in length. The encoded protein has 652 amino acids and the predicted molecular weight of the protein is 70.392 kilodaltons.

Function

The protein acts as a homodimer and is involved in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis.

Clinical significance

Mutations in the SLC20A2 gene are associated with idiopathic basal ganglia calcification (Fahr's syndrome). This association suggests that familial idiopathic basal ganglia calcification is caused by changes in phosphate homeostasis, since this gene encodes for PIT-2, an inorganic phosphate transporter.^[8]

See also

• Solute carrier family