SLC22A1

Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.^[5][6]

SLC22A1
Identifiers
Aliases	SLC22A1, HOCT1, OCT1, oct1_cds, solute carrier family 22 member 1
External IDs	OMIM: 602607; MGI: 108111; HomoloGene: 20665; GeneCards: SLC22A1; OMA:SLC22A1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 160,121,815 bp[1] End 160,158,718 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 8.63 cM Start 12,867,756 bp[2] End 12,894,716 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver cartilage tissue testicle blood granulocyte spleen stromal cell of endometrium left lobe of thyroid gland sural nerve gastrocnemius muscle Top expressed in right kidney left lobe of liver human kidney proximal tubule Ileal epithelium duodenum atrioventricular valve jejunum Paneth cell gallbladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function norepinephrine:sodium symporter activity protein homodimerization activity transmembrane transporter activity transporter activity acetylcholine transmembrane transporter activity monoamine transmembrane transporter activity protein binding identical protein binding secondary active organic cation transmembrane transporter activity quaternary ammonium group transmembrane transporter activity organic cation transmembrane transporter activity organic anion transmembrane transporter activity dopamine:sodium symporter activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane basolateral plasma membrane Biological process establishment or maintenance of transmembrane electrochemical gradient xenobiotic transmembrane transport quaternary ammonium group transport acetate ester transport cation transport ion transport monoamine transport norepinephrine transport epinephrine transport organic cation transport dopamine transport protein homooligomerization ammonium transmembrane transport transmembrane transport neurotransmitter transport organic anion transport norepinephrine uptake dopamine uptake Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6580 20517 Ensembl ENSG00000175003 ENSMUSG00000023829 UniProt O15245 O08966 RefSeq (mRNA) NM_003057 NM_153187 NM_009202 RefSeq (protein) NP_003048 NP_694857 NP_033228 Location (UCSC) Chr 6: 160.12 – 160.16 Mb Chr 17: 12.87 – 12.89 Mb PubMed search [3] [4]
Wikidata
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Function

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.^[6]

It is also required for the uptake of metformin by cells.^[7][8]

See also

• Solute carrier family
• Organic cation transport proteins