SLC22A18

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.^[5][6][7]

SLC22A18
Identifiers
Aliases	SLC22A18, BWR1A, BWSCR1A, HET, IMPT1, ITM, ORCTL2, SLC22A1L, TSSC5, p45-BWR1A, solute carrier family 22 member 18
External IDs	OMIM: 602631; MGI: 1336884; HomoloGene: 1918; GeneCards: SLC22A18; OMA:SLC22A18 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 2,899,721 bp[1] End 2,925,246 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.22 cM Start 143,027,473 bp[2] End 143,053,071 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum right lobe of liver human kidney right auricle of heart blood left testis right testis stromal cell of endometrium granulocyte Top expressed in right kidney human kidney lumbar spinal ganglion left lobe of liver proximal tubule duodenum gastric mucosa mucous cell of stomach epithelium of stomach pyloric antrum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function symporter activity xenobiotic transmembrane transporter activity ubiquitin protein ligase binding transporter activity transmembrane transporter activity Cellular component cytoplasm integral component of membrane plasma membrane nuclear envelope membrane apical plasma membrane Biological process organic cation transport excretion ion transport transmembrane transport xenobiotic transmembrane transport xenobiotic export transport xenobiotic transport xenobiotic detoxification by transmembrane export across the plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5002 18400 Ensembl ENSG00000276130 ENSG00000110628 ENSMUSG00000000154 UniProt Q96BI1 Q78KK3 RefSeq (mRNA) NM_002555 NM_183233 NM_001315501 NM_001315502 NM_001042760 NM_008767 RefSeq (protein) NP_001302430 NP_001302431 NP_002546 NP_899056 NP_001036225 NP_032793 Location (UCSC) Chr 11: 2.9 – 2.93 Mb Chr 7: 143.03 – 143.05 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.^[7]

See also

• Solute carrier family