SLC22A8

Solute carrier family 22 member 8, or organic anion transporter 3 (OAT3), is a protein that in humans is encoded by the SLC22A8 gene.^[5][6][7]

SLC22A8
Identifiers
Aliases	SLC22A8, OAT3, solute carrier family 22 member 8
External IDs	OMIM: 607581; MGI: 1336187; HomoloGene: 20901; GeneCards: SLC22A8; OMA:SLC22A8 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,989,154 bp[1] End 63,015,841 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,568,618 bp[2] End 8,589,199 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium kidney tubule metanephric glomerulus human kidney testicle renal medulla vena cava vasculature of head gonad Epithelium of choroid plexus Top expressed in right kidney human kidney retinal pigment epithelium optic nerve proximal tubule ciliary body olfactory tubercle lumbar subsegment of spinal cord pontine nuclei Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sodium-independent organic anion transmembrane transporter activity transmembrane transporter activity inorganic anion exchanger activity transporter activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane extracellular exosome membrane Biological process sodium-independent organic anion transport ion transport response to toxic substance transmembrane transport anion transmembrane transport inorganic anion transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9376 19879 Ensembl ENSG00000149452 ENSMUSG00000063796 UniProt Q8TCC7 O88909 RefSeq (mRNA) NM_001184732 NM_001184733 NM_001184736 NM_004254 NM_001164634 NM_001164635 NM_031194 RefSeq (protein) NP_001171661 NP_001171662 NP_001171665 NP_004245 NP_001158106 NP_001158107 NP_112471 Location (UCSC) Chr 11: 62.99 – 63.02 Mb Chr 19: 8.57 – 8.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

OAT3 is involved in the transport and excretion of organic ions some of which are drugs (e.g., penicillin G (benzylpenicillin), methotrexate (MTX), indomethacin (an NSAID), and ciprofloxacin (a fluoroquinolone antibiotic)) and some of which are pure toxicants.^[6] SLC22A8 (OAT3) is indirectly dependent on the inward sodium gradient, which is a driving force for reentry of dicarboxylates into the cytosol. Dicarboxylates, such as alpha-ketoglutarate generated within the cell, or recycled from the extracellular space, are used as exchange substrates to fuel the influx of organic anions against their concentration gradient. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of renal proximal tubule cells.^[7]