SLC2A9

Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene.^[5][6][7]

SLC2A9
Identifiers
Aliases	SLC2A9, solute carrier family 2 (facilitated glucose transporter), member 9, GLUT9, GLUTX, UAQTL2, URATv1, solute carrier family 2 member 9
External IDs	OMIM: 606142; MGI: 2152844; HomoloGene: 69290; GeneCards: SLC2A9; OMA:SLC2A9 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 9,771,153 bp[1] End 10,054,936 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B3 Start 38,506,616 bp[2] End 38,660,486 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell monocyte human kidney right lobe of liver testicle pancreatic ductal cell granulocyte gonad right lung salivary gland Top expressed in connecting tubule granulocyte zygote jejunum liver secondary oocyte primary oocyte morula distal tubule thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity carbohydrate:proton symporter activity glucose transmembrane transporter activity urate transmembrane transporter activity transmembrane transporter activity Cellular component apical plasma membrane basolateral plasma membrane plasma membrane membrane integral component of membrane nuclear envelope integral component of plasma membrane Biological process urate metabolic process carbohydrate transport transmembrane transport hexose transmembrane transport urate transport proton transmembrane transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56606 117591 Ensembl ENSG00000109667 ENSMUSG00000005107 UniProt Q9NRM0 Q3T9X0 RefSeq (mRNA) NM_001001290 NM_020041 NM_001012363 NM_001102414 NM_001102415 NM_145559 RefSeq (protein) NP_001001290 NP_064425 NP_001012363 NP_001095884 NP_001095885 NP_663534 Location (UCSC) Chr 4: 9.77 – 10.05 Mb Chr 5: 38.51 – 38.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.^[7]

SLC2A9 has also recently been found to transport uric acid, and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia, gout and Alzheimer's disease.^[8][9][10]

See also

• Glucose transporter
• Solute carrier family