SLC45A3

Solute carrier family 45 member 3 (SLC45A3), also known as prostate cancer-associated protein 6 or prostein, is a protein that in humans is encoded by the SLC45A3 gene.^[5][6][7]

SLC45A3
Identifiers
Aliases	SLC45A3, IPCA-2, IPCA-6, IPCA-8, IPCA6, PCANAP2, PCANAP6, PCANAP8, PRST, solute carrier family 45 member 3
External IDs	OMIM: 605097; MGI: 1922082; HomoloGene: 23813; GeneCards: SLC45A3; OMA:SLC45A3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,657,851 bp[1] End 205,680,509 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 131,890,705 bp[2] End 131,910,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prostate C1 segment oocyte nasal epithelium secondary oocyte mucosa of ileum right lobe of liver spleen inferior ganglion of vagus nerve mucosa of transverse colon Top expressed in secondary oocyte primary oocyte zygote gastric mucosa pyloric antrum mucous cell of stomach epithelium of stomach egg cell lumbar spinal ganglion right kidney More reference expression data BioGPS n/a
Gene ontology Molecular function sucrose:proton symporter activity sugar transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane Biological process transmembrane transport sucrose transport positive regulation of glucose metabolic process positive regulation of fatty acid biosynthetic process regulation of oligodendrocyte differentiation hexose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85414 212980 Ensembl ENSG00000158715 ENSMUSG00000026435 UniProt Q96JT2 Q8K0H7 RefSeq (mRNA) NM_033102 NM_001177628 NM_145977 RefSeq (protein) NP_149093 NP_001171099 NP_666089 Location (UCSC) Chr 1: 205.66 – 205.68 Mb Chr 1: 131.89 – 131.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SLC45A3 is expressed in a prostate-specific manner by normal tissues and at a significantly lower level in prostate tumor cell lines. Treatment of prostate cancer cell lines with androgens upregulates the expression of SLC45A3.^[7]

Immunohistochemistry of prostein in metastatic prostate adenocarcinoma to a lymph node, showing cytoplasmic staining.

Regulation

There is evidence that the expression of SLC45A3 is regulated by the microRNA mir-126*.^[8]